"Shake the Disease" is a song by English electronic music band Depeche Mode. Recorded at the Hansa Mischraum in Berlin, it was released as a single on 29 April 1985. "Shake the Disease" was one of two new songs on the 1985 compilation albums The Singles 81→85 and Catching Up with Depeche Mode, along with the band's subsequent single "It's Called a Heart".
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